STAT2 ELISA Kit for Human(Homo sapiens) | EIAab.comSTAT2 ELISA Kit for Human(Homo sapiens)

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STAT2 (Gene name),

Signal transducer and activator of transcription 2 (Protein name ), STAT2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

STAT2;

Protein name:

Signal transducer and activator of transcription 2;

Alternative:

p113;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with ISGF3G/IRF-9 in the cytoplasm. Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. Interacts with CRSP2 and CRSP6. Interacts with Simian virus 5 protein V and rabies virus phosphoprotein (By similarity). Can form a homodimer upon IFN-alpha induced phosphorylation. Interacts with IFNAR1; the interaction requires the phosphorylation of IFNAR1 at 'Tyr-466'. Interacts with IFNAR2. Interacts with dengue virus NS5; this interaction inhibits the phosphorylation of STAT2, and, when all viral proteins are present (polyprotein), targets STAT2 for degradation.

Function:

Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Subcellular Location:

Cytoplasm Nucleus Translocated into the nucleus upon activation by IFN-alpha/beta.

Protein Attributes:

Sequence length:

851

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

851:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P52630

SMR:

P52630

KEGG:

hsa:6773

Pfam:

PF00017

STRING:

9606.ENSP00000315768

UniGene:

Hs.530595

MIM:

600556

Uniprot:

P52630

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ELISA Kit for Human Signal transducer and activator of transcription 2

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E1796h

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96T

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ELISA Kit for Human Signal transducer and activator of transcription 2

Cat.:

E1796m

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MSDS:

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Packing:

96T

ELISA Kit for Human Signal transducer and activator of transcription 2

Cat.:

E1796p

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Packing:

96T

CLIA Kit for Human Signal transducer and activator of transcription 2

Cat.:

U1796m

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MSDS:

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Packing:

96T

CLIA Kit for Human Signal transducer and activator of transcription 2

Cat.:

U1796p

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Signal transducer and activator of transcription 2

Cat.:

U1796h

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Packing:

96T

Polyclonal Antibody for Human Signal transducer and activator of transcription 2

Cat.:

P1796Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Signal transducer and activator of transcription 2

Cat.:

P1796Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Signal transducer and activator of transcription 2

Protein for Human Signal transducer and activator of transcription 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction."
Fu X.-Y. , Schindler C. , Improta T. , Aebersold R. , Darnell J.E. Jr.
Proc. Natl. Acad. Sci. U.S.A.89:7840-7843(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE
2.

"The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2."
Yan R. , Qureshi S. , Zhong Z. , Wen Z. , Darnell J.E. Jr.
Nucleic Acids Res.23:459-463(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

NIEHS SNPs program
Submitted (2004-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS MET-448; VAL-464; ILE-594 AND HIS-826
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Tongue.
5.

"The finished DNA sequence of human chromosome 12."
Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Lung.
7.

"A transcription factor with SH2 and SH3 domains is directly activated by an interferon alpha-induced cytoplasmic protein tyrosine kinase(s)."
Fu X.Y.
Cell70:323-335(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION IN RESPONSE TO IFN-ALPHA
8.

"Role of STAT2 in the alpha interferon signaling pathway."
Leung S. , Qureshi S.A. , Kerr I.M. , Darnell J.E. Jr. , Stark G.R.
Mol. Cell. Biol.15:1312-1317(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-690;MUTAGENESIS OF TYR-690
9.

"Identification of alternative splicing form of Stat2."
Sugiyama T. , Nishio Y. , Kishimoto T. , Akira S.
FEBS Lett.381:191-194(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POTENTIAL ALTERNATIVE SPLICING
10.

"Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA."
Bluyssen H.A. , Levy D.E.
J. Biol. Chem.272:4600-4605(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT
11.

"Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling."
Li X. , Leung S. , Kerr I.M. , Stark G.R.
Mol. Cell. Biol.17:2048-2056(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IFNAR1 AND IFNAR2;PHOSPHORYLATION AT TYR-690
12.

"Viral inhibition of interferon signal transduction."
Cebulla C.M. , Miller D.M. , Sedmak D.D.
Intervirology42:325-330(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
13.

"Arginine/lysine-rich structural element is involved in interferon-induced nuclear import of STATs."
Melen K. , Kinnunen L. , Julkunen I.
J. Biol. Chem.276:16447-16455(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;MUTAGENESIS OF ARG-374; LYS-375; ARG-409 AND LYS-415
14.

"Role of metazoan mediator proteins in interferon-responsive transcription."
Lau J.F. , Nusinzon I. , Burakov D. , Freedman L.P. , Horvath C.M.
Mol. Cell. Biol.23:620-628(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CRSP2 AND CRSP6
15.

"Simian virus 5 V protein acts as an adaptor, linking DDB1 to STAT2, to facilitate the ubiquitination of STAT1."
Precious B. , Childs K. , Fitzpatrick-Swallow V. , Goodbourn S. , Randall R.E.
J. Virol.79:13434-13441(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIMIAN VIRUS 5 PROTEIN V
16.

"Binding STAT2 by the acidic domain of human cytomegalovirus IE1 promotes viral growth and is negatively regulated by SUMO."
Huh Y.H. , Kim Y.E. , Kim E.T. , Park J.J. , Song M.J. , Zhu H. , Hayward G.S. , Ahn J.H.
J. Virol.82:10444-10454(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HHV-5 PROTEIN UL123
17.

"NS5 of dengue virus mediates STAT2 binding and degradation."
Ashour J. , Laurent-Rolle M. , Shi P.Y. , Garcia-Sastre A.
J. Virol.83:5408-5418(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DENGUE VIRUS NS5
18.

"Dengue virus NS5 inhibits interferon-alpha signaling by blocking signal transducer and activator of transcription 2 phosphorylation."
Mazzon M. , Jones M. , Davidson A. , Chain B. , Jacobs M.
J. Infect. Dis.200:1261-1270(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DENGUE VIRUS NS5
19.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"Identification of STAT2 serine 287 as a novel regulatory phosphorylation site in type I interferon-induced cellular responses."
Steen H.C. , Nogusa S. , Thapa R.J. , Basagoudanavar S.H. , Gill A.L. , Merali S. , Barrero C.A. , Balachandran S. , Gamero A.M.
J. Biol. Chem.288:747-758(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-283; SER-287 AND THR-294;SUBCELLULAR LOCATION

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